Unitelma Sapienza also has research centers with operational autonomy:

• Research Center for "Distance Education and Technology Enhanced Learning", proposed and directed by Professor Umberto Nanni, Full Professor of "Enterprise Information Systems", in the Faculty of Engineering, Computer Science and Statistics, University of Rome "La Sapienza".

• IdEA - Research Centre Innovation, Development and Economic Applications proposed and directed by prof. Imbriani former Dean of the Faculty of Law at the university and director of the Legal Studies Department, philosophical and economic University of Rome "La Sapienza".

• Research Centre for European Law that aims to develop studies and research in the fields of European and international law which concern, on the one hand, the process of EU integration and relations that Union itself has developed and is developing and the institutional and regulatory relationships proposed and Directed by prof. Enzo Cannizzaro.

• Research Center “Legality, Security and Investigations” proposed and Directed by Prof. Giorgio Spangher former Head of Department of Law, University of Rome "La Sapienza".